Detection of human herpesvirus-6 DNA in bone marrow biopsies from patients with multiple myeloma and Waldenstrom’s macroglobulin-

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patients with multiple myeloma and Waldenstrom’s macroglobulinemia. Blood 91:4393, 1998 15. Brousset P, Meggetto F, Attal M, Delsol G: Kaposi’s sarcomaassociated herpesvirus infection and multiple myeloma. Science 278: 1972, 1997 16. Beksac M, Ma M, DerDanielian M, Zhang L, Liu J, Kuzu I, Erekul S, Vescio R, Berenson J: Frequent demonstration of human nerpesvirus 8 (HHV-8) in bone marrow samples from Turkish patients with multiple myeloma. Blood 92:96a, 1998 (abstr, suppl 1) 17. Ma H, Vescio R, DerDanielian M, Schiller G, Berenson J: The HHV-8 IL-8R homologue and interferon regulatory factor genes are frequently expressed in myeloma bone marrow biopsies whereas the vIL-6 is rarely found. Blood 92:515a, 1998 (abstr, suppl 1) 18. Whitby D, Howard M, Tenant-Flowers M, Brink N, Copas A, Boshoff C, Hatzioannout T, Suggett T, Aldam D, Denton A, Miller R, Weller I, Weiss R, Tedder R, Schulz T: Detection of Kaposi sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi’s sarcoma. Lancet 346:799, 1995 19. Rettig M, Vescio R, Moss T, Ma H, Schiller G, Berenson J: Detection of Kaposi’s sarcoma-associated herpesvirus in the peripheral blood of multiple myeloma patients. Blood 90:587a, 1997 (abstr, suppl 1) 20. Cull GM, Timms JM, Haynes A, Russell N, Irving W, Ball J, Thomson B: Dendritic cells cultured from mononuclear cells and CD34 cells in myeloma do not harbour human herpesvirus 8. Br J Haematol 100:793, 1998 21. Tarte K, Olsen S, Lu Z, Legouffe E, Rossi J-F, Chang Y, Klein B: Clinical-grade dendritic cells from patients with multiple myeloma are not infected with Kaposi’s sarcoma-associated herpesvirus. Blood 91:1852, 1998 22. Vieira J, Huang M-L, Koelle DM, Corey L: Transmissible Kaposi’s sarcoma-associate herpesvirus in saliva of men with a history of Kaposi’s sarcoma. J Virol 71:7083, 1997 23. Martin J, Ganem DE, Osmond DH, Page-Shafer K, Macrae D, Kedes D: Sexual transmission and the natural history of human herpesvirus 8 infection. N Engl J Med 338:948, 1998 24. Henick K, Vescio R, Ma M, DerDanielian M, Moss TJ, Berenson J: HHV-8 is rarely detected in the peripheral blood dendritic cells of close contacts of patients with multiple myeloma. Blood 92:96a, 1998 (abstr, suppl 1) 25. Zong J-C, Metroka C, Reitz MS, Nicholas J, Hayward GS: Strain variability among Kaposi sarcoma-associated herpesvirus (human herpes virus 8) genomes: Evidence that a large cohort of United States AIDS patients may have been infected by a common isolate. J Virol 71:2505, 1997 26. Rettig M, Vescio R, Ma H, Schiller G, Savage A, Berenson J: Sequence variability of HHV-8 from the dendritic cells of multiple myeloma patients. Blood 90:86a, 1997 (abstr, suppl 1) 27. Marcellin A-G, Dupin N, Buscary D, Bossi P, Cacoub P, Ravaud P, Calvez V: HHV-8 HHV-8 and multiple myeloma in France. Lancet 350:114, 1997 28. Mackenzie J, Sheldon J, Morgan G, Cook, Schulz T, Jarrett R: HHV-8 and multiple myeloma in the UK. Lancet 350:1144, 1997 29. Gao SJ, Alsina M, Deng J-H, Harrison C, Montalvo E, Leach C, Roodman GD, Jenson H: Antibodies to Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. J Infect Dis 178:846, 1998

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Detection of human herpesvirus-6 DNA in bone marrow biopsies from patients with multiple myeloma and Waldenstrom’s macroglobulin-

patients with multiple myeloma and Waldenstrom’s macroglobulinemia. Blood 91:4393, 1998 15. Brousset P, Meggetto F, Attal M, Delsol G: Kaposi’s sarcomaassociated herpesvirus infection and multiple myeloma. Science 278: 1972, 1997 16. Beksac M, Ma M, DerDanielian M, Zhang L, Liu J, Kuzu I, Erekul S, Vescio R, Berenson J: Frequent demonstration of human nerpesvirus 8 (HHV-8) in bone marrow sample...

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Detection of human herpesvirus-6 DNA in bone marrow biopsies from patients with multiple myeloma and Waldenstrom’s macroglobulin-

patients with multiple myeloma and Waldenstrom’s macroglobulinemia. Blood 91:4393, 1998 15. Brousset P, Meggetto F, Attal M, Delsol G: Kaposi’s sarcomaassociated herpesvirus infection and multiple myeloma. Science 278: 1972, 1997 16. Beksac M, Ma M, DerDanielian M, Zhang L, Liu J, Kuzu I, Erekul S, Vescio R, Berenson J: Frequent demonstration of human nerpesvirus 8 (HHV-8) in bone marrow sample...

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Frequency of FLT3 ITD and FLT3 TKD Mutations in Multiple Myeloma Patients (A Case Control Study)

Background and Aims: Multiple myeloma is a malignant proliferation of plasma cells derived from a single clone. The tumor, its products and the host response lead to organ damages. Some factors that are responsible in its pathogenesis are recognized. As FMS like Tyrosine Kinase 3 receptor (FLT3) mutation has been proved as a determining factor in leukemic patients the goal of this study was to ...

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Detection of human herpesvirus-8 DNA in bone marrow biopsies from patients with multiple myeloma and Waldenström's macroglobulinemia.

associated herpesvirus infection and multiple myeloma. Science 278: 1972, 1997 4. Rettig M, Vescio R, Ma H, Schiller G, Savage A, Berenson J: Sequence variability of HHV-8 from the dendritic cells of multiple myeloma patients. Blood 90:86a, 1997 (suppl 1) 5. Cathomas G, McGandy CE, Terracciano LM, Itin PH, De Rosa G, Gudat F: Detection of herpesvirus-like DNA by nested PCR on archival skin biop...

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In vitro Effect of Pomalidomide on Bone Marrow Mononuclear Cells from Multiple Myeloma Patients

Background: Many features of anticancer drugs, including cytotoxicity and/or cytokine induction, are studied using cell lines orhuman blood leukocytes. However, in a disease such as multiple myeloma, most cancerous cells are resided within bone marrowmononuclear cells. In the present study, we investigated the effect of pomalidomide on apoptosis and IL-2 production of bonemarrow mononuclear cel...

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تاریخ انتشار 1999